2025 Annual Report
Annual Report
January 2026 news from the Sec Gen
News

January 2026 news from the Sec Gen

Dear colleagues and friends,As we begin a new year, I would like to thank you for your continued engagement and trust in ECETOC. 2026 promises to be an exciting and dynamic year, and I am pleased...
ECETOC launches Secondee Programme
News

ECETOC launches Secondee Programme

Looking for an extra challenge? A next step to help develop your career? Consider applying for our Secondee Programme!ECETOC is looking for early-career scientists currently working at a member co...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why?Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....
Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Why?REACH restriction: SPM use restricted; emissions reporting required by May 2027. Gap: No analytical methods available to measure SPM emissions. Solution: Draft SPERC-based approac...
Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Why?Validation of NAMs is often overlooked despite its importance for regulatory use. Traditional validation methods are less suitable for NAMs, which focus on key events rather than apical...

Endocrine DisruptorsPFAS

Publications

Workshop Report no.30: The Role of Epigenetics in Reproductive Toxicity
Workshop Report

Workshop Report no.30: The Role of Epigenetics in Reproductive Toxicity

This workshop explored the current state of the science on epigenetics and its role in reproductive toxicity. Experts from a range of scientific disciplines met over two days to share knowledge and br...
Document

DOC 034 – The Challenge Posed by Endocrine Disrupting Chemicals

DOC 034 : The Challenge Posed by Endocrine-disrupting Chemicals | February 1996 ...
Document

DOC 032 – “Environmental Oestrogens”: Male Reproduction and Reproductive Development

DOC 032 : 'Environmental Oestrogens': Male Reproduction and Reproductive Development | January 1998The paper was developed to review the currently available data relevant to the putative effects o...
Monograph

Monograph 005 – Identification and Assessment of the Effects of Chemicals on Reproduction and Development (Reproductive Toxicology)

Mono 005 : Identification and Assessment of the Effects of Chemicals on Reproduction and Development (Reproductive Toxicology) | December 1983...
Document

DOC 013 – The Organisation of Jointly-Sponsored (ECO) Toxicological Studies

DOC 013 : The Organisation of Jointly-Sponsored (Eco)Toxicological Studies| December 1980ECETOC members sometimes participate in (eco) toxicological studies, jointly sponsored at a contract labora...
Document

DOC 012 – Criteria for Choosing Chemicals for Testing

DOC 012 : Criteria for Choosing Chemicals for Testing | December 1980...

Task Forces

Substances that activate various liver receptors as endocrine disruptors

Substances that activate various liver receptors as endocrine disruptors

Why? The current development of NAMs in the field of endocrine disruption (ED) is very active as the concept of ED is evolving in various areas of toxicology including liver toxicity/xenobiotic met...